BDBM212960 US9278960, 4-123::US9278960, 4-124::US9278960, 4-44::US9663506, Example 4-124

SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3CCCC(C3)C(F)(F)F)cc2n1

InChI Key InChIKey=JNCRVEGRUNRPPF-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 212960   

LigandPNGBDBM212960(US9278960, 4-123 | US9278960, 4-124 | US9278960, 4...)
Affinity DataIC50: 48nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212960(US9278960, 4-123 | US9278960, 4-124 | US9278960, 4...)
Affinity DataIC50: 48nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212960(US9278960, 4-123 | US9278960, 4-124 | US9278960, 4...)
Affinity DataIC50: 48nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212960(US9278960, 4-123 | US9278960, 4-124 | US9278960, 4...)
Affinity DataIC50: 49nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent

LigandPNGBDBM212960(US9278960, 4-123 | US9278960, 4-124 | US9278960, 4...)
Affinity DataIC50: 49nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212960(US9278960, 4-123 | US9278960, 4-124 | US9278960, 4...)
Affinity DataIC50: 49nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

LigandPNGBDBM212960(US9278960, 4-123 | US9278960, 4-124 | US9278960, 4...)
Affinity DataIC50: 59nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212960(US9278960, 4-123 | US9278960, 4-124 | US9278960, 4...)
Affinity DataIC50: 59nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM212960(US9278960, 4-123 | US9278960, 4-124 | US9278960, 4...)
Affinity DataIC50: 59nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent