BDBM213058 US9278960, 6-5::US9636337, 6-5

SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(Cc3cccnc3)cc2n1

InChI Key InChIKey=JRGRWIMAJDQCPG-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 213058   

TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213058(US9278960, 6-5 | US9636337, 6-5)
Affinity DataKi:  6.70nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213058(US9278960, 6-5 | US9636337, 6-5)
Affinity DataIC50: 47nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213058(US9278960, 6-5 | US9636337, 6-5)
Affinity DataIC50: 47nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent

LigandPNGBDBM213058(US9278960, 6-5 | US9636337, 6-5)
Affinity DataIC50: 47nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
Go to US Patent