BDBM213683 US9278981, 275

SMILES CC(F)(F)Oc1ccc(NC(=O)c2cnc(N3CC[C@@H](O)C3)c(c2)-c2cncc(F)c2)cc1

InChI Key InChIKey=NGQGLANDYRFTKE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 213683   

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Novartis

US Patent
LigandPNGBDBM213683(US9278981, 275)
Affinity DataIC50: 2.80nMpH: 7.5 T: 2°CAssay Description:The assay plates were prepared by addition of 50 nL per well of compound solution in 90% DMSO. The kinase reactions were started by stepwise addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Novartis

US Patent
LigandPNGBDBM213683(US9278981, 275)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:For determination of ABL kinase activity, the radiometric filter-binding assay was used. The assay was performed by mixing 10 uL of the compound pre-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2017
Entry Details
US Patent