BDBM213882 8-(4-chloro-3- methoxyphenyl)-6- {[(1r)-1- cyclobutylethyl]amino}- 7-[4- (trifluoromethyl)benzyl]- 7h-purine-2-carboxylic acid::US9540377, 1.124

SMILES COc1cc(ccc1Cl)-c1nc2nc(nc(N[C@H](C)C3CCC3)c2n1Cc1ccc(cc1)C(F)(F)F)C(O)=O

InChI Key InChIKey=NNMMJTGNAOSLLA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 213882   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 213882BDBM213882(US9540377, 1.124 | 8-(4-chloro-3- methoxyphenyl)-6...)
Affinity DataIC50: 26.4nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent