BDBM214688 US9295672, (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol

SMILES Cc1cc(Nc2nc(nc3ccccc23)C(O)c2ccc(F)cc2)n[nH]1

InChI Key

Data  7 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 214688   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214688(US9295672, (4-fluorophenyl)(4-((5-methyl-1H-pyraz...)
Affinity DataKd:  6.00E+3nMT: 2°CAssay Description:For the binding assays, streptavidin-coated magnetic beads were treated with biotinylated affinity ligands for 30 min at room temperature to generate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214688(US9295672, (4-fluorophenyl)(4-((5-methyl-1H-pyraz...)
Affinity DataKd:  300nMT: 2°CAssay Description:For the binding assays, streptavidin-coated magnetic beads were treated with biotinylated affinity ligands for 30 min at room temperature to generate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214688(US9295672, (4-fluorophenyl)(4-((5-methyl-1H-pyraz...)
Affinity DataKd:  1.05E+4nMT: 2°CAssay Description:For the binding assays, streptavidin-coated magnetic beads were treated with biotinylated affinity ligands for 30 min at room temperature to generate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214688(US9295672, (4-fluorophenyl)(4-((5-methyl-1H-pyraz...)
Affinity DataKd:  1.80E+3nMT: 2°CAssay Description:For the binding assays, streptavidin-coated magnetic beads were treated with biotinylated affinity ligands for 30 min at room temperature to generate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214688(US9295672, (4-fluorophenyl)(4-((5-methyl-1H-pyraz...)
Affinity DataIC50: <310nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214688(US9295672, (4-fluorophenyl)(4-((5-methyl-1H-pyraz...)
Affinity DataIC50:  1.09E+4nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C8(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214688(US9295672, (4-fluorophenyl)(4-((5-methyl-1H-pyraz...)
Affinity DataIC50:  2.31E+4nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214688(US9295672, (4-fluorophenyl)(4-((5-methyl-1H-pyraz...)
Affinity DataIC50:  1.74E+4nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214688(US9295672, (4-fluorophenyl)(4-((5-methyl-1H-pyraz...)
Affinity DataIC50:  1.47E+4nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214688(US9295672, (4-fluorophenyl)(4-((5-methyl-1H-pyraz...)
Affinity DataIC50: >4.00E+4nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2B6(Homo sapiens (Human))
Ambit Biosciences

US Patent
LigandPNGBDBM214688(US9295672, (4-fluorophenyl)(4-((5-methyl-1H-pyraz...)
Affinity DataIC50: >4.00E+4nMT: 2°CAssay Description:The ability of the R and S enantiomers of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol to inhibit the common drug met...More data for this Ligand-Target Pair
In DepthDetails US Patent