BDBM214831 US9296734, 31

SMILES Cc1cc(Cl)cnc1C(=O)Nc1ccc(F)c(c1)[C@]1(C)C[C@H](OC(N)=N1)C(F)(F)F

InChI Key InChIKey=FLOQLFHUIOTUTO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 214831   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM214831(US9296734, 31)
Affinity DataIC50: 14.4nMT: 2°CAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2017
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM214831(US9296734, 31)
Affinity DataIC50: 16.5nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2017
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM214831(US9296734, 31)
Affinity DataIC50: 2.02E+5nMpH: 3.5Assay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2017
Entry Details
US Patent