BDBM21814 2-[4-(3-{[(1S)-1-(carboxymethyl)-2,3-dihydro-1H-inden-5-yl]oxy}propoxy)-3-propylphenyl]-4-(hydroxymethyl)-1,3-thiazole-5-carboxylic acid::Indanylacetic Acid Analog, 34ac

SMILES CCCc1cc(ccc1OCCCOc1ccc2[C@H](CC(O)=O)CCc2c1)-c1nc(CO)c(s1)C(O)=O

InChI Key InChIKey=DZROKMVTHSSOLL-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 21814   

TargetPeroxisome proliferator-activated receptor delta(Human)
Bayer Healthcare Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 21814BDBM21814(2-[4-(3-{[(1S)-1-(carboxymethyl)-2,3-dihydro-1H-in...)
Affinity DataEC50:  12nMT: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Healthcare Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 21814BDBM21814(2-[4-(3-{[(1S)-1-(carboxymethyl)-2,3-dihydro-1H-in...)
Affinity DataEC50:  891nMT: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Healthcare Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 21814BDBM21814(2-[4-(3-{[(1S)-1-(carboxymethyl)-2,3-dihydro-1H-in...)
Affinity DataEC50:  6.49E+3nMT: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Healthcare Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 21814BDBM21814(2-[4-(3-{[(1S)-1-(carboxymethyl)-2,3-dihydro-1H-in...)
Affinity DataEC50:  1.54E+5nMAssay Description:Agonist activity at GST-tagged Homo sapiens (human) PPARalpha ligand binding domain after 2 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Healthcare Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 21814BDBM21814(2-[4-(3-{[(1S)-1-(carboxymethyl)-2,3-dihydro-1H-in...)
Affinity DataEC50:  1.15E+6nMAssay Description:Agonist activity at Homo sapiens (human) PPARgamma expressed in mouse 3T3-L1 cells incubated for 2 days followed by compound wash out measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article