BDBM218221 6-{[(1r)-1- cyclobutyl- ethyl]amino)-8- (3,4-dichloro- phenyl)-7-[4- (trifluoromethyl) benzyl]-7h- purine-2- carboxylic acid::US9540377, 2.76

SMILES C[C@@H](Nc1nc(nc2nc(-c3ccc(Cl)c(Cl)c3)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O)C1CCC1

InChI Key InChIKey=DEUFQSQHJZQORB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 218221   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 218221BDBM218221(US9540377, 2.76 | 6-{[(1r)-1- cyclobutyl- ethyl]am...)
Affinity DataIC50: 20.4nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent