BDBM218230 US9249087, Table 1 , Compound 7

SMILES CN1CCN(CCc2cn(-c3ccc(cc3)C(=O)NO)c3ccccc23)CC1

InChI Key InChIKey=BGQZROPCHZVPNL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 218230   

TargetHistone deacetylase 6(Human)
University of Illinois

US Patent
LigandPNGBDBM218230(US9249087, Table 1 , Compound 7)
Affinity DataIC50: 2.94nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
University of Illinois

US Patent
LigandPNGBDBM218230(US9249087, Table 1 , Compound 7)
Affinity DataIC50: 174nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
University of Illinois

US Patent
LigandPNGBDBM218230(US9249087, Table 1 , Compound 7)
Affinity DataIC50: 1.23E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent