BDBM218596 7-[1-4- chlorophenyl)ethyl]-6- [(cyclopropylmethyl)amino]- 8-(3-methylphenyl)-7h- purine-2-carboxylic acid::US9540377, 5.2

SMILES CC(c1ccc(Cl)cc1)n1c(nc2nc(nc(NCC3CC3)c12)C(O)=O)-c1cccc(C)c1

InChI Key InChIKey=SVPIXLNJNWQONY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 218596   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 218596BDBM218596(US9540377, 5.2 | 7-[1-4- chlorophenyl)ethyl]-6- [(...)
Affinity DataIC50: 984nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent