BDBM218631 6-{[(1r)-1- cyclopropylethyl]amino}- 7-(2-ethoxy-5- (trifluoromethyl)benzyl)-8- (3-methylphenyl)-7h- purine-2-carboxylic acid::US9540377, 5.5

SMILES C[C@H]1Nc2nc(nc3nc(-c4cccc(C)c4)n(Cc4cc(ccc4OCC4CC14)C(F)(F)F)c23)C(O)=O

InChI Key InChIKey=AUCWQFKTNOLLSY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 218631   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 218631BDBM218631(US9540377, 5.5 | 6-{[(1r)-1- cyclopropylethyl]amin...)
Affinity DataIC50: 2.74E+3nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent