BDBM218662 6-{[(1r)-1- cyclopropylethyl]amino}- 7-[3-fluoro-4- (trifluoromethyl)benzyl]-8- (3-methylphenyl)-7h- purine-2-carboxylic acid::US9540377, 5.9

SMILES Cc1cccc(-c2nc3c(n2Cc2ccc(C(F)(F)F)c(F)c2)C(N[C@H](C)C2CC2)NC(C(=O)O)=N3)c1

InChI Key InChIKey=PYCUGXUUUDZMCT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 218662   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 218662BDBM218662(US9540377, 5.9 | 6-{[(1r)-1- cyclopropylethyl]amin...)
Affinity DataIC50: 119nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent