BDBM220114 7-(4-chlorobenzyl)-6- {[(1r)-1- cyclohexylethyl]amino}- 8-(3-methylphenyl)- 7h-purine-2- carboxylic acid::US9540377, 6.4

SMILES C[C@@H](Nc1nc(nc2nc(-c3cccc(C)c3)n(Cc3ccc(Cl)cc3)c12)C(O)=O)C1CCCCC1

InChI Key InChIKey=LIJXUXAESBVPDC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 220114   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 220114BDBM220114(US9540377, 6.4 | 7-(4-chlorobenzyl)-6- {[(1r)-1- c...)
Affinity DataIC50: 1.03E+3nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent