BDBM220145 7-(4-bromobenzyl)-6- [(2- methylcyclohexyl)amino]- 8-(3- methylphenyl)-7h- purine-2-carboxylic acid::US9540377, 6.10::US9540377, 6.9

SMILES CC1CCCCC1Nc1nc(nc2nc(-c3cccc(C)c3)n(Cc3ccc(Br)cc3)c12)C(O)=O

InChI Key InChIKey=WSKKVKRUQGEOPT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 220145   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 220145BDBM220145(US9540377, 6.9 | US9540377, 6.10 | 7-(4-bromobenzy...)
Affinity DataIC50: 22.3nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 220145BDBM220145(US9540377, 6.9 | US9540377, 6.10 | 7-(4-bromobenzy...)
Affinity DataIC50: 1.04E+3nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent