BDBM220232 6-[(2,4- dimethylcyclohexyl) amino]-8-(3- methylphenyl)-7[-4- (trifluoromethyl)benzyl]- 7h-purine-2- carboxylic acid::US9540377, 6.33::US9540377, 6.34

SMILES CC1CCC(Nc2nc(nc3nc(-c4cccc(C)c4)n(Cc4ccc(cc4)C(F)(F)F)c23)C(O)=O)C(C)C1

InChI Key InChIKey=YGTRVALLWFTWAH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 220232   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 220232BDBM220232(US9540377, 6.33 | US9540377, 6.34 | 6-[(2,4- dimet...)
Affinity DataIC50: 305nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 220232BDBM220232(US9540377, 6.33 | US9540377, 6.34 | 6-[(2,4- dimet...)
Affinity DataIC50: 1.14E+3nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent