BDBM220243 6-{[1-(2- methylcyclopropyl) ethyl]amino}-8-(3- methylphenyl)-7 -[4- (trifluoromethyl)benzyl]- 7h-purine-2- carboxylic acid::US9540377, 6.37::US9540377, 6.38

SMILES CC(Nc1nc(nc2nc(-c3cccc(C)c3)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O)C1CC1C

InChI Key InChIKey=PQYYBDGEUUYYOJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 220243   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 220243BDBM220243(US9540377, 6.37 | US9540377, 6.38 | 6-{[1-(2- meth...)
Affinity DataIC50: 360nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 220243BDBM220243(US9540377, 6.37 | US9540377, 6.38 | 6-{[1-(2- meth...)
Affinity DataIC50: 530nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent