BDBM220273 6-{[(s)- cyclobutyl(phenyl) methhyl]amino}-8-[4-(1- methylethyl)pyridin-2- yl]-7-[4- (trifluoromethyl)benzyl]- 7h-purine-2- carboxylic acid::US9540377, 6.58::US9540377, 7.16

SMILES CC(C)c1ccnc(c1)-c1nc2nc(nc(N[C@@H](C3CCC3)c3ccccc3)c2n1Cc1ccc(cc1)C(F)(F)F)C(O)=O

InChI Key InChIKey=FINLGEULGOVMAL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 220273   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 220273BDBM220273(US9540377, 6.58 | 6-{[(s)- cyclobutyl(phenyl) meth...)
Affinity DataIC50: 40.6nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 220273BDBM220273(US9540377, 6.58 | 6-{[(s)- cyclobutyl(phenyl) meth...)
Affinity DataIC50: 49.2nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent