BDBM221457 6-[(2r)-2- cyclobutylpyrrolidin- 1-yl]-8-(3- methylphenyl)-7-[4- (trifluoromethyl)benzyl]- 7h-purine-2- carboxylic acid::US9540377, 7.8

SMILES Cc1cccc(c1)-c1nc2nc(nc(N3CCC[C@@H]3C3CCC3)c2n1Cc1ccc(cc1)C(F)(F)F)C(O)=O

InChI Key InChIKey=YJKYVHSYOAOEFI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221457   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 221457BDBM221457(US9540377, 7.8 | 6-[(2r)-2- cyclobutylpyrrolidin- ...)
Affinity DataIC50: 188nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent