BDBM221466 8-2-methoxy-5- methylphenyl)-6-{[1- (3- methylcyclobutyl)ethyl]- amino}-7-[4- (trifluoromethyl)benzyl]- 7h-purine-2- carboxylic acid::US9540377, 7.18

SMILES COc1ccc(C)cc1-c1nc2nc(C(=O)O)nc(NC(C)C3CC(C)C3)c2n1Cc1ccc(C(F)(F)F)cc1

InChI Key InChIKey=DRGJMOZHSPYPFJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221466   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 221466BDBM221466(US9540377, 7.18 | 8-2-methoxy-5- methylphenyl)-6-{...)
Affinity DataIC50: 163nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent