BDBM221497 (2r)-2-[(6- {[(1r)-1- cyclobutylethyl]amino}- 7-[4- (trifluoromethyl)benzyl]- 7h-purin-8- yl)amino]-2- phenylethanol::US9540377, 9.29

SMILES C[C@@H](Nc1ncnc2nc(N[C@@H](CO)c3ccccc3)n(Cc3ccc(cc3)C(F)(F)F)c12)C1CCC1

InChI Key InChIKey=CILXIHWCIWXIDQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221497   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 221497BDBM221497(US9540377, 9.29 | (2r)-2-[(6- {[(1r)-1- cyclobutyl...)
Affinity DataIC50: 4.47E+3nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent