BDBM222705 6-{[(1r)-1- cyclobutylethyl]amino}-8- [propyl(1-pyridin-2- ylethyl)amino]-7-[4- (trifluoromethyl)benzyl]- 7h-purine-2-carboxylic acid::US9540377, 10.32

SMILES CCCN(C(C)c1ccccn1)c1nc2nc(nc(N[C@H](C)C3CCC3)c2n1Cc1ccc(cc1)C(F)(F)F)C(O)=O

InChI Key InChIKey=KYBCQTLEZZVZAW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 222705   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 222705BDBM222705(US9540377, 10.32 | 6-{[(1r)-1- cyclobutylethyl]ami...)
Affinity DataIC50: 3.72nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent