BDBM222707 6-{[(1r)-1- cyclobutylethyl]amino}-8- (1-ethyl-4-methylpiperidin- 2-yl)-7-[(trans-4- methylcyclohexyl)methyl]- 7h-purine-2-carboxylic acid::US9540377, 10.34

SMILES CCN1CCC(C)CC1c1nc2nc(C(=O)O)nc(N[C@H](C)C3CCC3)c2n1C[C@H]1CC[C@H](C)CC1

InChI Key InChIKey=BADDXNWQCSGWPA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 222707   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 222707BDBM222707(US9540377, 10.34 | 6-{[(1r)-1- cyclobutylethyl]ami...)
Affinity DataIC50: 5.98nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent