BDBM223626 6-{[(1r)-1- cyclobutylethyl]amino}- 8-(2- ethylpiperidin-1-yl)- 7-[(trans-4- methylcyclohexyl) methyl]-7h-purine-2- carboxylic acid::US9540377, 11.52

SMILES CCC1CCCCN1c1nc2nc(C(=O)O)nc(N[C@H](C)C3CCC3)c2n1C[C@H]1CC[C@H](C)CC1

InChI Key InChIKey=BWKLZMMSBGCBQU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223626   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223626BDBM223626(US9540377, 11.52 | 6-{[(1r)-1- cyclobutylethyl]ami...)
Affinity DataIC50: 3.43nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent