BDBM223654 3-(6-{[(1r)-1- cyclobutylethyl]amino}- 8-(4,4- difluoropiperidin-1- yl)-7-[(trans-4- methylcyclohexyl) methyl]-7h-purin-2- yl)-1,2,4-oxadiazol- 5(2h)-one::US9540377, 11.80

SMILES C[C@@H](Nc1nc(-c2noc(=O)[nH]2)nc2nc(N3CCC(F)(F)CC3)n(C[C@H]3CC[C@H](C)CC3)c12)C1CCC1

InChI Key InChIKey=LIRWZUZURXKJMD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223654   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223654BDBM223654(US9540377, 11.80 | 3-(6-{[(1r)-1- cyclobutylethyl]...)
Affinity DataIC50: 25.9nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent