BDBM223664 3-(6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- methylcyclohexyl) methyl]-8-{[1-(3- methyl-1,2,4- oxadiazol-5- yl)ethyl]amino}-7h- purin-2-yl)-1,2,4- oxadiazol-5(2h)-one::US9540377, 11.90

SMILES Cc1noc(C(C)Nc2nc3nc(-c4noc(=O)[nH]4)nc(N[C@H](C)C4CCC4)c3n2C[C@H]2CC[C@H](C)CC2)n1

InChI Key InChIKey=ITKZVZIARDUKKS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223664   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223664BDBM223664(US9540377, 11.90 | 3-(6-{[(1r)-1- cyclobutylethyl]...)
Affinity DataIC50: 4.04nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent