BDBM223699 5-[6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- methylcyclohexyl) methyl]-8-(octahydro- 4h-1,4-benzoxazin- 4-yl)-7h-purin-2-yl]- 1,3,4-oxadiazol- 2(3h)-one (diastereomer 1)::US9540377, 11.125::US9540377, 11.126

SMILES C[C@@H](Nc1nc(-c2n[nH]c(=O)o2)nc2nc(N3CCOC4CCCCC43)n(C[C@H]3CC[C@H](C)CC3)c12)C1CCC1

InChI Key InChIKey=PEXHJBUQRMZUIW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 223699   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223699BDBM223699(US9540377, 11.125 | US9540377, 11.126 | 5-[6-{[(1r...)
Affinity DataIC50: 1.46nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223699BDBM223699(US9540377, 11.125 | US9540377, 11.126 | 5-[6-{[(1r...)
Affinity DataIC50: 7.49nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent