BDBM223704 3-[6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- methylcyclohexyl) methyl]-8-(2- phenylpyrrolidin-1- yl)-7h-purin-2-yl]- 1,2,4-oxadiazol- 5(4h)-one::US9540377, 11.130::US9540377, 11.135::US9540377, 11.136
SMILES C[C@@H](Nc1nc(-c2noc(=O)[nH]2)nc2nc(N3CCCC3c3ccccc3)n(C[C@H]3CC[C@H](C)CC3)c12)C1CCC1
InChI Key InChIKey=MKJFDNYTOBOXDJ-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 223704
Affinity DataIC50: 2.05nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Affinity DataIC50: 2.08nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Affinity DataIC50: 514nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair