BDBM223743 1-(6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- methylcyclohexyl)methyl]- 8-[4-(propan-2- yl)pyridin-2-yl]-7h- purin-2-yl)ethanone::US9540377, 12.5

SMILES CC(=O)c1nc(N[C@H](C)C2CCC2)c2c(n1)nc(-c1cc(C(C)C)ccn1)n2C[C@H]1CC[C@H](C)CC1

InChI Key InChIKey=HMOHRHDMBGJWKS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223743   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223743BDBM223743(US9540377, 12.5 | 1-(6-{[(1r)-1- cyclobutylethyl]a...)
Affinity DataIC50: 471nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent