BDBM223758 1-(6-(((r)-1- cyclobutylethyl)amino)-7- ((trans-4- methylcyclohexyl)methyl)- 8-((r)-3- phenylmorpholino)-7h- purin-2-yl)ethane-1,2-diol::US9540377, 12.20

SMILES C[C@@H](Nc1nc(C(O)CO)nc2nc(N3CCOC[C@H]3c3ccccc3)n(C[C@H]3CC[C@H](C)CC3)c12)C1CCC1

InChI Key InChIKey=VTVLEDOTHDKDQM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223758   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223758BDBM223758(US9540377, 12.20 | 1-(6-(((r)-1- cyclobutylethyl)a...)
Affinity DataIC50: 49.4nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent