BDBM223770 6-{[(1r)-1- cyclobutylethyl]amino}-n- methoxy-8-[4-(1- methylethyl)pyridin-2-yl]-7- [4-(trifluoromethyl)benzyl]- 7h-purine-2-carboxamide::US9540377, 12.32

SMILES CONC(=O)c1nc(N[C@H](C)C2CCC2)c2n(Cc3ccc(cc3)C(F)(F)F)c(nc2n1)-c1cc(ccn1)C(C)C

InChI Key InChIKey=JIXONLGOLPIQBO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223770   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223770BDBM223770(US9540377, 12.32 | 6-{[(1r)-1- cyclobutylethyl]ami...)
Affinity DataIC50: 42.5nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent