BDBM224069 6-{[(1r)-1- cyclobutylethyl)amino}- 8-(2-methoxy-5- methylphenyl)-7-[(trans- 4- methylcyclohexyl)methyl]- 7h-purine-2- carboxylic acid::US9540377, 15.13

SMILES COc1ccc(C)cc1-c1nc2nc(C(=O)O)nc(N[C@H](C)C3CCC3)c2n1C[C@H]1CC[C@H](C)CC1

InChI Key InChIKey=KJISKSMHIVVUCY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224069   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224069BDBM224069(US9540377, 15.13 | 6-{[(1r)-1- cyclobutylethyl)ami...)
Affinity DataIC50: 4.96nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent