BDBM224076 8-(4-tert-butylpyridin-2- yl)-6-{[(1r)-1- cyclobutylethyl](methyl) amino}-7-[(trans-4- methylcyclohexyl)methyl]- 7h-purine-2- carboxylic acid::US9540377, 15.20

SMILES C[C@H](C1CCC1)N(C)c1nc(C(=O)O)nc2nc(-c3cc(C(C)(C)C)ccn3)n(C[C@H]3CC[C@H](C)CC3)c12

InChI Key InChIKey=SYNJOROXUMJBRU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224076   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224076BDBM224076(US9540377, 15.20 | 8-(4-tert-butylpyridin-2- yl)-6...)
Affinity DataIC50: 17.9nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent