BDBM224084 5-(7-(((trans)-4- methylcyclohexyl) methyl)-8-morpholino- 6-(m-tolyl)-7h-purin- 2-yl)-1,3,4-oxadiazol- 2(3h)-one::US9540377, 16.3

SMILES Cc1cccc(-c2nc(-c3n[nH]c(=O)o3)nc3nc(N4CCOCC4)n(C[C@H]4CC[C@H](C)CC4)c23)c1

InChI Key InChIKey=PMFDZQKXJZFHFW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224084   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224084BDBM224084(US9540377, 16.3 | 5-(7-(((trans)-4- methylcyclohex...)
Affinity DataIC50: 563nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent