BDBM224089 3-(6-(3- chlorophenyl)-8- (((1r,2s)-2-hydroxy- 1- phenylpropyl)amino)- 7-(((trans)-4- methylcyclohexyl) methyl)-7h-purin-2-yl)- 1,2,4-oxadiazol- 5(4h)-one::US9540377, 16.8

SMILES C[C@H](O)[C@H](Nc1nc2nc(-c3noc(=O)[nH]3)nc(-c3cccc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)c1ccccc1

InChI Key InChIKey=OAOIGKKHTADXJZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224089   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224089BDBM224089(US9540377, 16.8 | 3-(6-(3- chlorophenyl)-8- (((1r,...)
Affinity DataIC50: 1.49nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent