BDBM224205 5-{6-(3- chlorophenyl)-8- (hexahydro-2h- pyrano[4,3-b]pyridin- 1(5h)-yl)-7-[(trans-4- methylcyclohexyl) methyl]-7h-purin-2-yl}- 1,3,4-oxadiazol- 2(3h)-one (stereoisomer 1)::US9540377, 16.124::US9540377, 16.125

SMILES C[C@H]1CC[C@H](Cn2c(N3CCCC4COCCC43)nc3nc(-c4n[nH]c(=O)o4)nc(-c4cccc(Cl)c4)c32)CC1

InChI Key InChIKey=QKMDPCIHIPAEBY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224205   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224205BDBM224205(US9540377, 16.124 | US9540377, 16.125 | 5-{6-(3- c...)
Affinity DataIC50: 56.7nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224205BDBM224205(US9540377, 16.124 | US9540377, 16.125 | 5-{6-(3- c...)
Affinity DataIC50: 263nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent