BDBM224227 5-{6-(5- chloropyridin-3-yl)- 7-[(trans-4- methylcyclohexyl) methyl]-8-[2-(3-methyl- 1,2,4-oxadiazol-5- yl)pyrrolidin-1-yl]- 7h-purin-2-yl}-1,3,4- oxadiazol-2(3h)-one (racemate)::US9540377, 16.146

SMILES Cc1noc(C2CCCN2c2nc3nc(-c4n[nH]c(=O)o4)nc(-c4cncc(Cl)c4)c3n2C[C@H]2CC[C@H](C)CC2)n1

InChI Key InChIKey=NRUAEEHPNZLUFU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224227   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224227BDBM224227(US9540377, 16.146 | 5-{6-(5- chloropyridin-3-yl)- ...)
Affinity DataIC50: 3.04nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent