BDBM224245 3-{6-(5-chloro-2- methylpyridin-3-yl)- 8-[(trans)- hexahydrocyclopenta [b][1,4]oxazin- 4(4ah)-yl]-7-[(trans- 4- methylcyclohexyl) methyl]-7h-purin-2-yl}- 1,2,4-oxadiazol- 5(4h)-one (racemate)::US9540377, 16.164

SMILES Cc1ncc(Cl)cc1-c1nc(-c2noc(=O)[nH]2)nc2nc(N3CCOC4CCCC43)n(C[C@H]3CC[C@H](C)CC3)c12

InChI Key InChIKey=YXAWTPXTJVBMAL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224245   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224245BDBM224245(US9540377, 16.164 | 3-{6-(5-chloro-2- methylpyridi...)
Affinity DataIC50: 2.09nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent