BDBM224260 3-(8-((r)-4-acetyl-2- methylpiperazin-1- yl)-6-(((r)-1- cyclobutylethyl) amino)-7-((trans-4- methylcyclohexyl) methyl)-7h-purin-2-yl)- 1,2,4-oxadiazol- 5(4h)-one::US9540377, 17.9

SMILES CC(=O)N1CCN(c2nc3nc(-c4noc(=O)[nH]4)nc(N[C@H](C)C4CCC4)c3n2C[C@H]2CC[C@H](C)CC2)[C@H](C)C1

InChI Key InChIKey=ZTTMFDQAVKWEPY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224260   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224260BDBM224260(US9540377, 17.9 | 3-(8-((r)-4-acetyl-2- methylpipe...)
Affinity DataIC50: 2.61nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent