BDBM224274 3-(6-{[(1r)-1- cyclobutylethyl]amino}- 8-[(2r,5s)-4- (cyclopropylcarbonyl)- 2,5- dimethylpiperazin-1- yl]-7-[(trans-4- methylcyclohexyl) methyl]-7h-purin-2- yl)-1,2,4-oxadiazol- 5(4h)-one::US9540377, 17.23

SMILES C[C@@H]1CN(C(=O)C2CC2)[C@@H](C)CN1c1nc2nc(-c3noc(=O)[nH]3)nc(N[C@H](C)C3CCC3)c2n1C[C@H]1CC[C@H](C)CC1

InChI Key InChIKey=LZNKBZCBLAOCOW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224274   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224274BDBM224274(US9540377, 17.23 | 3-(6-{[(1r)-1- cyclobutylethyl]...)
Affinity DataIC50: 4.88nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent