BDBM224280 6-(((r)-1-cyclobutylethyl)amino)-7- ((4-ethylcyclohex-3-en-1-yl)methyl)- 8-(4-isopropylpyridin-2-yl)-7h- purine-2-carboxylic acid::US9540377, 18.24::US9540377, 18.6

SMILES CCC1=CCC(Cn2c(-c3cc(C(C)C)ccn3)nc3nc(C(=O)O)nc(N[C@H](C)C4CCC4)c32)CC1

InChI Key InChIKey=PAUIFCDPECLBBQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224280   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224280BDBM224280(US9540377, 18.6 | US9540377, 18.24 | 6-(((r)-1-cyc...)
Affinity DataIC50: 15.9nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224280BDBM224280(US9540377, 18.6 | US9540377, 18.24 | 6-(((r)-1-cyc...)
Affinity DataIC50: 15.9nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent