BDBM224285 3-(6-(((r)-1-cyclobutylethyl)amino)- 7-((trans-3,3-difluoro-4- methylcyclohexyl)methyl)-8-(4- isopropylpyridin-2-yl)-7h-purin-2- yl)-1,2,4-oxadiazol-5(4h)-one::US9540377, 18.11

SMILES CC(C)c1ccnc(-c2nc3nc(-c4noc(=O)[nH]4)nc(N[C@H](C)C4CCC4)c3n2CC2CCC(C)C(F)(F)C2)c1

InChI Key InChIKey=XXQKWAZXUHZAQD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224285   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224285BDBM224285(US9540377, 18.11 | 3-(6-(((r)-1-cyclobutylethyl)am...)
Affinity DataIC50: 2.79nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent