BDBM224292 6-{[(1r)-1-cyclobutylethyl]amino}- 7-[(trans-4-ethylcyclohexyl)methyl]- 8-piperidin-1-yl-7h-purine-2- carboxylic acid::US9540377, 18.18

SMILES CC[C@H]1CC[C@H](Cn2c(N3CCCCC3)nc3nc(C(=O)O)nc(N[C@H](C)C4CCC4)c32)CC1

InChI Key InChIKey=GWPRCJXFUGASJX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224292   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224292BDBM224292(US9540377, 18.18 | 6-{[(1r)-1-cyclobutylethyl]amin...)
Affinity DataIC50: 8.60nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent