BDBM224294 3-(6-{[(1r)-1- cyclobutylethyl]amino}-7-[(trans-4- ethylcyclohexyl)methyl]-8-[4-(1- methylethyl)pyridin-2-yl]-7h-purin- 2-yl)-1,2,4-oxadiazol-5(4h)-one::US9540377, 18.20

SMILES CC[C@H]1CC[C@H](Cn2c(-c3cc(C(C)C)ccn3)nc3nc(-c4noc(=O)[nH]4)nc(N[C@H](C)C4CCC4)c32)CC1

InChI Key InChIKey=PINKEAWPRIBVAN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224294   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224294BDBM224294(US9540377, 18.20 | 3-(6-{[(1r)-1- cyclobutylethyl]...)
Affinity DataIC50: 15.7nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent