BDBM224301 6-{[(1r)-1-cyclopropylethyl]amino}- 8-(3-methylphenyl)-7-{[4- (trifluoromethyl)cyclohexyl]methyl}- 7h-purine-2-carboxylic acid (stereoisomer 1)::US9540377, 18.27::US9540377, 18.28

SMILES Cc1cccc(-c2nc3nc(C(=O)O)nc(N[C@H](C)C4CC4)c3n2CC2CCC(C(F)(F)F)CC2)c1

InChI Key InChIKey=QGVJPMCAJMOYPW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224301   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224301BDBM224301(US9540377, 18.27 | 6-{[(1r)-1-cyclopropylethyl]ami...)
Affinity DataIC50: 338nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224301BDBM224301(US9540377, 18.27 | 6-{[(1r)-1-cyclopropylethyl]ami...)
Affinity DataIC50: 386nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent