BDBM224313 5-{6-(3-chlorophenyl)-8- (hexahydrocyclopenta[b][1,4]oxazin- 4(4ah)-yl)-7-[1-(trans-4- methylcyclohexyl)ethyl]-7h-purin-2- yl}-1,3,4-oxadiazol-2(3h)-one (stereoisomer 1)::US9540377, 18.39::US9540377, 18.43

SMILES CC([C@H]1CC[C@H](C)CC1)n1c(N2CCOC3CCCC32)nc2nc(-c3n[nH]c(=O)o3)nc(-c3cccc(Cl)c3)c21

InChI Key InChIKey=XNWPVENFUDXILR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224313   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224313BDBM224313(US9540377, 18.39 | 5-{6-(3-chlorophenyl)-8- (hexah...)
Affinity DataIC50: 3.73nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224313BDBM224313(US9540377, 18.39 | 5-{6-(3-chlorophenyl)-8- (hexah...)
Affinity DataIC50: 14.0nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent