BDBM224321 5-{6-(5-chloropyridin-3-yl)-8-[(2s)- 2-(fluoromethyl)pyrrolidin-1-yl]-7- [1-(trans-4-methylcyclohexyl)ethyl]- 7h-purin-2-yl}-1,3,4-oxadiazol- 2(3h)-one (diastereomer 1)::US9540377, 18.47::US9540377, 18.48

SMILES CC([C@H]1CC[C@H](C)CC1)n1c(N2CCC[C@H]2CF)nc2nc(-c3n[nH]c(=O)o3)nc(-c3cncc(Cl)c3)c21

InChI Key InChIKey=QOUVOZVYMFPRDH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224321   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224321BDBM224321(US9540377, 18.47 | US9540377, 18.48 | 5-{6-(5-chlo...)
Affinity DataIC50: 5.14nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224321BDBM224321(US9540377, 18.47 | US9540377, 18.48 | 5-{6-(5-chlo...)
Affinity DataIC50: 8.12nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent