BDBM224537 US10080750, Compound 220::US9321760, 220::US9662330, Compound 220

SMILES Nc1ncnc(N2CCC(N)(CC2)C(=O)N[C@H](c2ccc(Cl)cc2)C(F)(F)F)c1C#N

InChI Key InChIKey=UKBYBWXPHLYWKC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 224537   

TargetRibosomal protein S6 kinase beta-1(Human)
Merck Patent

US Patent
LigandPNGBDBM224537(US9321760, 220 | US10080750, Compound 220 | US9662...)
Affinity DataIC50: 3.20E+3nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase beta-1(Human)
Merck Patent

US Patent
LigandPNGBDBM224537(US9321760, 220 | US10080750, Compound 220 | US9662...)
Affinity DataIC50: 3.20E+3nMpH: 7.5Assay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandPNGBDBM224537(US9321760, 220 | US10080750, Compound 220 | US9662...)
Affinity DataIC50: 3.20E+3nMpH: 7.5Assay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent