BDBM224668 5-[6-(5-chloro-1- oxidopyridin-3-yl)-7- [(trans-4- methylcyclohexyl)methyl]- 8-(1-phenylcyclobutyl)- 7h-purin-2-yl]-1,3,4- oxadiazol-2(3h)-one::US9540377, 20.13

SMILES C[C@H]1CC[C@H](Cn2c(C3(c4ccccc4)CCC3)nc3nc(-c4n[nH]c(=O)o4)nc(-c4cc(Cl)c[n+]([O-])c4)c32)CC1

InChI Key InChIKey=BQJUJZGZEPNJRJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224668   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224668BDBM224668(US9540377, 20.13 | 5-[6-(5-chloro-1- oxidopyridin-...)
Affinity DataIC50: 22.8nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent