BDBM224669 3-[6-(5-chloro-2- methoxypyridin-3-yl)-7- [(trans-4- methylcyclohexyl)methyl]- 8-(1-phenylcyclobutyl)- 7h-purin-2-yl]-1,2,4- oxadiazol-5(4h)-one::US9540377, 20.14

SMILES COc1ncc(Cl)cc1-c1nc(-c2noc(=O)[nH]2)nc2nc(C3(c4ccccc4)CCC3)n(C[C@H]3CC[C@H](C)CC3)c12

InChI Key InChIKey=RDLTYEWUABKHPL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224669   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224669BDBM224669(US9540377, 20.14 | 3-[6-(5-chloro-2- methoxypyridi...)
Affinity DataIC50: 6.12nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent