BDBM224736 3-(6-{[(1r)-1- cyclobutylethyl]amino}-7- [(trans-4- methylcyclohexyl)methyl]-8- [(1r or s)-2,2,2-trifluoro-1- hydroxy-1-phenylethyl]-7h- purin-2-yl)-1,2,4-oxadiazol- 5(4h)-one (isomer 1)::US9540377, 22.25::US9540377, 22.28

SMILES C[C@@H](Nc1nc(-c2noc(=O)[nH]2)nc2nc(C(O)(c3ccccc3)C(F)(F)F)n(C[C@H]3CC[C@H](C)CC3)c12)C1CCC1

InChI Key InChIKey=LXDAFEBFCQOCIU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224736   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224736BDBM224736(US9540377, 22.25 | US9540377, 22.28 | 3-(6-{[(1r)-...)
Affinity DataIC50: 27.3nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224736BDBM224736(US9540377, 22.25 | US9540377, 22.28 | 3-(6-{[(1r)-...)
Affinity DataIC50: 501nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent